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Invitrogen™ Mouse VISTA/B7-H5/PD-1H ELISA Kit
ELISA
Merk: Invitrogen™ EM74RBX5
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Beschrijving
Mouse VISTA/B7-H5/PD-1H quantitates mouse VISTA/B7-H5/PD-1H in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse VISTA/B7-H5/PD-1H.
VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1 it has a different expression pattern. In both mouse and humans, VISTA is expressed predominantly on hematopoietic cells with the highest densities on myeloid cells, and lower levels on T cells. It is usually absent on B cells. VISTA expressed by antigen presenting cells has been shown to directly suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a target for cancer immunotherapy. The reported ligands of VISTA include CD28H, VSIG-3 and VSIG-8.
Specificatie
| 4632428N05Rik; B7H5; B7-H5; C10orf54; chromosome 10 open reading frame 54; DD1alpha; Death Domain1alpha; Dies1; differentiation of ESCs 1; GI24; PD-1 H; PDCD1 homolog; PD-H1; platelet receptor Gi24; PP2135; RIKEN cDNA 4632428N05 gene; SISP1; sisp-1; Stress-induced secreted protein-1; UNQ730/PRO1412; V-domain Ig suppressor of T cell activation; VISTA; V-set domain-containing immunoregulatory receptor; V-set immunoregulatory receptor; Vsir; V-type immunoglobulin domain-containing suppressor of T-cell activation | |
| 3 ng/mL | |
| ELISA | |
| Colorimetric Microplate Reader | |
| VSIR | |
| <10 | |
| HRP | |
| RUO | |
| 2°C to 8°C | |
| 1 hrs 20 mins |
| 3 to 600 ng/mL | |
| HRP | |
| Plasma, Serum, Supernatant | |
| 74048 | |
| <12% | |
| Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers | |
| 5 x 96 Tests | |
| Plasma 50 μL, Serum 50 μL, Supernatant 50 μL | |
| VISTA | |
| 4 hrs 45 mins |
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