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MIB1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Merk:  Invitrogen PA553924

Produktcode. 15731861

  • 554.00 / 100 µL

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Beschrijving

Beschrijving

Immunogen sequence: LDLEIVQSLQ HGHGGWTDGM FETLTTTGTV CGIDEDHDIV VQYPSGNRWT FNPAVLTKAN IVRSGDAAQG AEGGTSQFQV GDLVQVCYDL ERIKLLQRGH GEWAEAM Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
TRUSTED_SUSTAINABILITY
Specificatie

Specificatie

MIB1
Polyclonal
Unconjugated
MIB1
DAPK-interacting protein 1; DAPK-interacting protein-1; DIP1; DIP-1; E3 ubiquitin-protein ligase MIB1; E430019M12Rik; KIAA1323; LVNC7; MIB; MIB1; Mind bomb homolog 1; mind bomb-1; mindbomb E3 ubiquitin protein ligase 1; mindbomb homolog 1; mindbomb homolog 1 (Drosophila); mKIAA1323; RING-type E3 ubiquitin transferase MIB1; skeletrophin; ubiquitin ligase mind bomb; zinc finger ZZ type with ankyrin repeat domain protein 2; ZZANK2; ZZZ6
Rabbit
Antigen affinity chromatography
RUO
57534
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunocytochemistry, Immunohistochemistry
0.2 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q86YT6
MIB1
Recombinant protein corresponding to Human MIB1
100 μL
Primary
Human
Antibody
IgG
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