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  7. Thermo Scientific Chemicals Chloroquine diphosphate salt, 98%

Thermo Scientific Chemicals Chloroquine diphosphate salt, 98%

Chloroquine diphosphate salt, CAS # 50-63-5, is a member of the quinolone family that is considered to be a DNA intercalator. It shows anti-malarial, anti-inflammatory, and anti-filaricides activities.

49.95 - 379.89

Chemische identificatiekenmerken

CAS 50-63-5
Moleculaire formule C18H32ClN3O8P2
Molecular Weight (g/mol) 515.86
MDL-nummer MFCD00069852
InChI Key QKICWELGRMTQCR-UHFFFAOYNA-N
Synoniem chloroquine diphosphate, chloroquine phosphate, aralen phosphate, chingamin phosphate, chloroquine bis phosphate, chingaminum, alermine, h-stadur, aralen diphosphate, miniquine
PubChem CID 64927
IUPAC Name 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid
SMILES OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC=C1
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Produktcode Merk Aantal Prijs Hoeveelheid en beschikbaarheid  
Produktcode Merk Aantal Prijs Hoeveelheid en beschikbaarheid  
15368865
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Description

Description

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Information


• Chloroquine diphosphate salt is a DNA intercalator that shows anti-malarial and anti-inflammatory activities.
• It has been described that this compound interferes with the biosynthesis of nucleic acids, suggesting a cellular mechanism of action


Applications

• Chloroquine diphosphate salt is used as a DNA intercalator to dissociate antigen-antibody complexes without denaturing red blood cell antigens
• This compound shows anti-malarial activity against Plasmodium falciparum, except against chloroquine-resistant strains. It has been used in in vitro antiplasmodial assays. In parasites the mechanism of action remains unclear, but this compound can inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemozoin, resulting in the accumulation of toxic heme within the parasite.
• It shows very high anti-viral activity against NiV but lower activity against other viruses at concentrations lower than 20 μM
• Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs
• Chloroquine diphosphate salt has been used in autophagy inhibition studies

Specifications

Chemical Identifiers

50-63-5
515.86
QKICWELGRMTQCR-UHFFFAOYNA-N
64927
OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC=C1
C18H32ClN3O8P2
MFCD00069852
chloroquine diphosphate, chloroquine phosphate, aralen phosphate, chingamin phosphate, chloroquine bis phosphate, chingaminum, alermine, h-stadur, aralen diphosphate, miniquine
4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid

Specifications

Chloroquine diphosphate salt
200.0°C
Authentic
C18H32ClN3O8P2
chloroquine diphosphate, chloroquine phosphate, aralen phosphate, chingamin phosphate, chloroquine bis phosphate, chingaminum, alermine, h-stadur, aralen diphosphate, miniquine
QKICWELGRMTQCR-UHFFFAOYNA-N
4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid
64927
98%
50-63-5
2% max. (105°C, 16 h)
97.5% min. (HPLC)
MFCD00069852
Solubility in water: 50g/L. Other solubilities: insoluble in alcohol, benzene, chloroform, ether
OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC=C1
515.86
515.86
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Safety and Handling

Safety and Handling

GHS H Statement
Harmful if swallowed.

GHS P Statement
IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.

GHS Signal Word: Warning

missing translation for 'einecsNumber' : 200-055-2

Product Identifier
  • Chloroquine diphosphate salt

Signal Word
  • Waarschuwing

Hazard Category
  • Acute toxiciteit Categorie 4

Hazard Statement
  • H302-Schadelijk bij inslikken.

Precautionary Statement
  • P264-Na het werken met dit product grondig wassen.
  • P301+P312-NA INSLIKKEN: bij onwel voelen een ANTIGIFCENTRUM / arts/ raadplegen.

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