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CBFA2T2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Merk: Proteintech 11336-1-AP-20UL
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Beschrijving
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5′-region of the RUNX1 (AML1) gene fused to the 3′-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.Specificatie
| CBFA2T2 | |
| Polyclonal | |
| Unconjugated | |
| CBFA2T2 | |
| CBFA2T2, EHT, MTG8 like protein, MTG8 related protein 1, MTGR1, p85, Protein CBFA2T2, ZMYND3 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 12396, 296293, 9139 | |
| -20°C | |
| Liquid |
| Western Blot, Immunohistochemistry (Paraffin) | |
| 0.8 mg/mL | |
| PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
| O43439, O70374 | |
| CBFA2T2 | |
| CBFA2T2 Fusion Protein Ag1880 | |
| 20 μL | |
| Primary | |
| Mouse, Rat, Human | |
| Antibody | |
| IgG |
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