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Calsequestrin 2 Mouse anti-Human, Mouse, Porcine, Rat, Clone: 1C10A1, Proteintech
Mouse Monoclonal Antibody
Brand: Proteintech 66419-1-IG-20UL
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Description
Calsequestrin (CASQ) is a Ca2+-binding protein present primarily in junctional sarcoplasmic reticulum of skeletal and cardiac muscle; the cardiac form (CASQ2) is encoded by a separate gene. The primary role of CASQ2 is buffering of the sarcoplasmic reticulum Ca2+ ions, but another role for CASQ2 has emerged recently: CASQ2 regulates the open probability of ryanodine receptor 2 (RyR2). Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.Specifications
| Calsequestrin 2 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| O09161, O14958, O18934, P51868 | |
| Casq2 | |
| Calsequestrin 2 Fusion Protein Ag13246 | |
| 20 μL | |
| Primary | |
| Human, Pig, Mouse, Rat | |
| Antibody | |
| IgG2a |
| Immunohistochemistry (Paraffin), Western Blot | |
| 1C10A1 | |
| Unconjugated | |
| CASQ2 | |
| Calsequestrin 2, CASQ2, PDIB2 | |
| Mouse | |
| Protein A | |
| RUO | |
| 12373, 29209, 397436, 845 | |
| -20°C | |
| Liquid |
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