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  6. Thermo Scientific Chemicals 4-Epitetracycline hydrochloride, can be used as a secondary standard

Thermo Scientific Chemicals 4-Epitetracycline hydrochloride, can be used as a secondary standard

4-Epitetracycline hydrochloride, CAS # 23313-80-6, is a degradation product of tetracycline that shows antibiotic activity and can induce the protein biosynthesis inhibition.

289.13 - 993.95

Chemische identificatiekenmerken

CAS 23313-80-6
Moleculaire formule C22H24N2O8·HCl
Molecular Weight (g/mol) 480.89
MDL-nummer MFCD00865028
InChI Key YCIHPQHVWDULOY-DXDJYCPMSA-N
Synoniem 4-epitetracycline hydrochloride, epitetracycline hydrochloride, 4-epi-tetracycline hydrochloride, quatrimycin hydrochloride, epitetracycline hcl, unii-i7c3edl2yg, i7c3edl2yg, epitetracycline hydrochloride usp, 4r,4as,5as,6s,12as-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
PubChem CID 54686189
IUPAC Name (4R,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride
SMILES CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl
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Produktcode Merk Aantal Verpakking Prijs Hoeveelheid en beschikbaarheid  
Produktcode Merk Aantal Verpakking Prijs Hoeveelheid en beschikbaarheid  
10358320
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Thermo Scientific Chemicals
233121000 		100 mg Glass bottle
289.13
100 mg
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10318370
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Thermo Scientific Chemicals
233125000 		500 mg Glass bottle
993.95
500 mg
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Beschrijving

Beschrijving

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • 4-Epitetracycline hydrochloride is a metabolite derived from the degradation of tetracycline compounds and has been shown to display antibiotic activity
  • This compound blocks protein synthesis by binding to the 30S ribosomal subunit and interfering with the binding of aminoacyl-tRNA to the mRNA-ribosome complex

Applications

  • This semi-synthesized compound derived from actinomycetes can decrease the activity of the Tet repressor effector in animal models
  • In vivo experiments revealed that 4-epitetracycline hydrochloride can induce a toxic response
Specificatie

Chemische identificatiekenmerken

23313-80-6
480.89
YCIHPQHVWDULOY-DXDJYCPMSA-N
54686189
CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl
C22H24N2O8·HCl
MFCD00865028
4-epitetracycline hydrochloride, epitetracycline hydrochloride, 4-epi-tetracycline hydrochloride, quatrimycin hydrochloride, epitetracycline hcl, unii-i7c3edl2yg, i7c3edl2yg, epitetracycline hydrochloride usp, 4r,4as,5as,6s,12as-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
(4R,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride

Specificatie

4-Epitetracycline hydrochloride
217.0°C
Authentic
C22H24N2O8·HCl
− 322.00
Solubility in water: 100g/L. Other solubilities: 100g/L methanol
CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl
480.89
480.89
Fine Crystalline Powder
23313-80-6
Yellow
80% min. (as is,calculated)
MFCD00865028
4-epitetracycline hydrochloride, epitetracycline hydrochloride, 4-epi-tetracycline hydrochloride, quatrimycin hydrochloride, epitetracycline hcl, unii-i7c3edl2yg, i7c3edl2yg, epitetracycline hydrochloride usp, 4r,4as,5as,6s,12as-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
YCIHPQHVWDULOY-DXDJYCPMSA-N
(4R,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride
54686189
≥97.0% Total Base (on anhydrous substance), ≥80 wt% (as is, calculated) (HPLC)
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Veiligheid en behandeling

Veiligheid en behandeling

GHS H Statement:
Causes serious eye irritation.
Suspected of damaging the unborn child.

GHS P Statement:
Use personal protective equipment as required.
Wear protective gloves/protective clothing/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

GHS Signal Word: Warning

missing translation for 'rtecsNumber' : QJ1898250

Productidentificatie
  • 4-Epitetracycline hydrochloride

Signaalwoord
  • Waarschuwing

Gevarencategorie
  • Ernstig oogletsel/oogirritatie Categorie 2
  • Giftigheid voor de voortplanting Categorie 2

Gevarenaanduiding
  • H361d-Wordt ervan verdacht het ongeboren kind te schaden.
  • H319-Veroorzaakt ernstige oogirritatie.

Veiligheidsmaatregel
  • P280-Beschermende handschoenen/beschermende kleding/oog­bescherming/gelaatsbescherming dragen.
  • P305+P351+P338-BIJ CONTACT MET DE OGEN: voorzichtig afspoelen met water gedurende een aantal minuten; contactlenzen verwijderen, indien mogelijk; blijven spoelen.

SDS
Documentatie

Documentatie

Product Certifications

RUO – Research Use Only

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