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BD Caspase-8
Play role in apoptosis induced by death receptors
Merk: BD 556481
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Beschrijving
Caspases are cysteine proteases that play central role in apoptosis. The caspase family was discovered by searching human cDNA libraries for sequences homologous to ced-3, a C. elegans death gene that is required for normal apoptosis during development
- Fas and tumor necrosis factor receptor type 1 (TNFR1)
- One of its substrates is poly (ADP ribose) polymerase (PARP)
- PARP is an enzyme that is involved in DNA repair and genomic maintenance
- Cleaves PARP from its 116kDa form to 85kDa residual fragment
- The cleavage site in PARP is C-terminal to Asp-216
- Utilized as basis for highly specific caspase-3 substrates such as Ac(N-acetyl)-DEVD-AFC (7-amino-4-trifluoromethylcourmarin) and Ac(N-acetyl)-DEVD-AMC (7-amino-4-methylcoumarin) as well as caspase-3 aldehyde inhibitor Ac-DEVD-CHO
- Format: Purified
Fluorescence quantitation
Specificatie
| 0.2mg/mL | |
| Human Caspase-8 Protease Recombinant Protein | |
| -80°C | |
| Recombinant |
| Fluorescence Quantitation | |
| 5μg | |
| Human |
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